USP32
Chr 17ubiquitin specific peptidase 32
Also known as: NY-REN-60, USP10
Enables cysteine-type deubiquitinase activity. Involved in positive regulation of TORC1 signaling. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
0
Active trials
0
Pathogenic / LP
0
ClinVar variants
8
Pubs (1 yr)
3.3
Missense Z· constrained
0.22
LOEUF· LoF intolerant
Clinical Summary— USP32
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 1.00). One damaged copy is likely sufficient to cause disease.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Dual constrained — LoF & missense intolerant
LoF Constraint
0.22LOEUF
pLI 1.000
Z-score 7.65
OE 0.14 (0.09–0.22)
Highly LoF-intolerant (top ~10% of genes)
Missense Constraint
3.28Z-score
OE missense 0.68 (0.64–0.73)
576 obs / 844.3 exp
Highly missense-constrained (top ~0.1%)
Observed / Expected Ratios
LoF OE0.14 (0.09–0.22)
0≤0.351.4
Missense OE0.68 (0.64–0.73)
0≤0.61.4
Synonymous OE0.85
0≤1.21.6
LoF obs/exp: 13 / 92.3Missense obs/exp: 576 / 844.3Syn Z: 2.03
ClinVar Variant Classifications
0 submitted variants in ClinVar
USP32 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target
Li S et al.·Cell Death Discov
2023Functional
Understanding The Regulatory Role of USP32 and SHMT2 in The Progression of Gastric Cancer
Li J et al.·Cell J
2023
Lycobetaine Has Therapeutic Efficacy in Lung Squamous Cell Carcinoma by Targeting USP32 to Trigger Ferroptosis
Xing S et al.·Curr Issues Mol Biol
2025
LAMTOR1 ubiquitination restricts its interaction with the vacuolar-type H+-ATPase, promotes autophagy and is controlled by USP32.
Hertel A et al.·Autophagy
2023
USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.
Hertel A et al.·Cell Rep
2022
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
Phosphorylation of USP32 by CDK5 regulates Rap1 stability and therapeutic resistance in pancreatic ductal adenocarcinoma.
Jiang Y et al.·Oncogene
2025
USP32 Promotes Colorectal Carcinoma Progression Through Activating NF-κB Signalling Pathway.
Duan X et al.·J Cell Mol Med
2025
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Dou N et al.·Int J Biol Sci
2020
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
USP32 promotes temporomandibular joint osteoarthritis by modulating PKM2 stability and glycolytic metabolism in chondrocytes.
Zhao J et al.·Cell Death Dis
2025Open Access
Comprehensive analysis of disulfidptosis-related genes in pulmonary hypertension through machine learning and immune infiltration: Spotlight on USP32 and ZNF655 as key regulators.
Chen R et al.·PLoS One
2025Open Access
USP32 stabilizes SEMA4C to promote malignant behavior of colon cancer cells.
Huang S et al.·Pathol Res Pract
2025
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools