USP17L11
Chr 4ubiquitin specific peptidase 17 like family member 11
The protein functions as a deubiquitinating enzyme that removes ubiquitin from specific proteins to regulate cell proliferation, cell cycle progression, apoptosis, and cellular responses to viral infection. Currently, no established human diseases have been definitively linked to mutations in this gene. The inheritance pattern and clinical significance remain to be determined as this gene lacks well-documented pathogenic variants in clinical databases.
Population Genetics & Constraint
Constraint data not available from gnomAD.
The highest-scoring mechanism for this gene is gain-of-function.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
USP17L11 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools