UGT2B4

Chr 4

UDP glucuronosyltransferase family 2 member B4

Also known as: HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11

NCBI Gene: 7363 ENSG00000156096 UniProt: P06133 OMIM: 600067

The UGT2B4 protein is a UDP-glucuronosyltransferase that conjugates lipophilic substrates with glucuronic acid to facilitate their excretion, playing an essential role in drug detoxification and metabolism of endogenous compounds including estrogen hormones. Mutations in UGT2B4 have not been established as a cause of human disease based on the available data. The gene shows low constraint against loss-of-function variants (LOEUF 1.22), suggesting tolerance to such mutations.

OMIM ResearchSummary from RefSeq, UniProt

Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.22

LOEUF

Mechanism· predicted