UGT2B10

Chr 4

UDP glucuronosyltransferase family 2 member B10

Also known as: UDPGT2B10

NCBI Gene: 7365ENSG00000109181UniProt: P36537

Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
11
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.64
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.64LOEUF
pLI 0.000
Z-score -0.71
OE 1.17 (0.85–1.64)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-2.86Z-score
OE missense 1.49 (1.38–1.62)
397 obs / 265.8 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.17 (0.85–1.64)
0≤0.351.4
Missense OE?1.49 (1.38–1.62)
0≤0.61.4
Synonymous OE?1.30
0≤1.21.6
LoF obs/exp: 24 / 20.5Missense obs/exp: 397 / 265.8Syn Z: -2.31

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

UGT2B10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients