UBL7

Chr 15

ubiquitin like 7

Also known as: BMSC-UbP, TCBA1

NCBI Gene: 84993 ENSG00000138629 UniProt: Q96S82 OMIM: 609748

Enables protein-macromolecule adaptor activity. Involved in antiviral innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIM Research

Enables protein-macromolecule adaptor activity. Involved in antiviral innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 400

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in UBL7?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 150

438 rare PASS variants

Rare truncating (LoF)

1 in 2,800

57 rare PASS variants

Rare synonymous (reference)

1 in 250

155 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for UBL7. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 240	1 in 5,600
South Asian	~43k	1 in 130	1 in 6,200
Remaining (unassigned)	~30k	1 in 170	1 in 6,000
European (Finnish)	~27k	1 in 830	1 in 3,100
Admixed American	~22k	1 in 150	1 in 550
African / African American	~21k	1 in 170	1 in 1,400
East Asian	~20k	1 in 130	1 in 2,600
Ashkenazi Jewish	~13k	1 in 330	none seen
Middle Eastern	~2,884	1 in 190	≈ 1 in 1,400

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.