UBE3D

Chr 6

ubiquitin protein ligase E3D

Also known as: C6orf157, H10BH, UBE2CBP, YJR141W

Enables several functions, including cyclin binding activity; ribonuclease inhibitor activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
P/LP submissions
P/LP missense
0.99
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
0.99LOEUF
pLI 0.000
Z-score 1.60
OE 0.62 (0.400.99)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.28Z-score
OE missense 0.94 (0.841.06)
196 obs / 207.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.62 (0.400.99)
00.351.4
Missense OE?0.94 (0.841.06)
00.61.4
Synonymous OE?1.06
01.21.6
LoF obs/exp: 13 / 20.9Missense obs/exp: 196 / 207.5Syn Z: -0.46

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

UBE3D · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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