UBAP2

Chr 9

ubiquitin associated protein 2

Also known as: UBAP-2

The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ResearchGenerating clinical summary…
0
Active trials
7
Pubs (1 yr)
P/LP submissions
P/LP missense
0.52
LOEUF
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint?
0.52LOEUF
pLI 0.000
Z-score 4.68
OE 0.36 (0.260.52)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
-0.11Z-score
OE missense 1.01 (0.951.08)
628 obs / 620.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.36 (0.260.52)
00.351.4
Missense OE?1.01 (0.951.08)
00.61.4
Synonymous OE?1.04
01.21.6
LoF obs/exp: 23 / 63.2Missense obs/exp: 628 / 620.3Syn Z: -0.50

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

UBAP2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →