TVP23B
Chr 17trans-golgi network vesicle protein 23 homolog B
Also known as: CGI-148, FAM18B, FAM18B1, NPD008, YDR084C
Predicted to be involved in protein secretion and vesicle-mediated transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jun 2026]
ResearchGenerating clinical summary…
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.05LOEUF
pLI 0.001
Z-score 1.44
OE 0.56 (0.32–1.05)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.67Z-score
OE missense 0.82 (0.69–0.98)
90 obs / 109.8 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.56 (0.32–1.05)
0≤0.351.4
Missense OE?0.82 (0.69–0.98)
0≤0.61.4
Synonymous OE?1.02
0≤1.21.6
LoF obs/exp: 7 / 12.5Missense obs/exp: 90 / 109.8Syn Z: -0.11
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TVP23B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools