TUSC8
Chr 13tumor suppressor candidate 8
Also known as: LINC01071, XLOC_010588
TUSC8 encodes a long non-coding RNA that enables miRNA inhibitor activity through base-pairing and is involved in post-transcriptional gene silencing. Currently, no established Mendelian diseases have been definitively linked to mutations in this gene. The inheritance pattern and clinical phenotypes associated with TUSC8 variants remain to be determined.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
27 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 27 |
Likely Pathogenic | — | — | — | — | 0 |
VUS | — | — | — | — | 0 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 27 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TUSC8 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools