TUBGCP5

Chr 15

tubulin gamma complex component 5

Also known as: GCP5

NCBI Gene: 114791ENSG00000275835UniProt: Q96RT8

Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome; ciliary basal body; and cytosol. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
12
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.67
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.67LOEUF
pLI 0.000
Z-score 3.63
OE 0.50 (0.37–0.67)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.37Z-score
OE missense 0.83 (0.77–0.90)
456 obs / 546.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.50 (0.37–0.67)
0≤0.351.4
Missense OE?0.83 (0.77–0.90)
0≤0.61.4
Synonymous OE?1.08
0≤1.21.6
LoF obs/exp: 30 / 60.5Missense obs/exp: 456 / 546.1Syn Z: -0.85

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TUBGCP5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients