TTTY4

Chr Y

testis expressed transcript, Y-linked 4

Also known as: LINC00123, NCRNA00123, TTTY4A, TTY4

TTTY4 encodes a Y chromosome-specific transcript of unknown function that is expressed exclusively in males. The clinical significance of mutations in this gene has not been established, and no specific disease associations have been reported in the medical literature. This gene follows Y-linked inheritance, being passed from father to son.

Summary from RefSeq
Research Assistant →
0
Active trials
0
Pubs (1 yr)
77
P/LP submissions
P/LP missense
LOEUF
Mechanism
Clinical SummaryTTTY4
📋
ClinVar Variants
77 unique Pathogenic / Likely Pathogenic· 13 VUS of 101 total submissions

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

101 submitted variants in ClinVar

Classification Summary

Pathogenic75
Likely Pathogenic2
VUS13
Likely Benign10
Benign1
75
Pathogenic
2
Likely Pathogenic
13
VUS
10
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
75
Likely Pathogenic
2
VUS
13
Likely Benign
10
Benign
1
Total101

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TTTY4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found