TTTY3

Chr Y

testis expressed transcript, Y-linked 3

Also known as: LINC00121, NCRNA00121, TTTY3A, TTY3

The protein function of TTTY3 is not well characterized, as this Y chromosome-encoded gene has limited functional annotation. Clinical disease associations with TTTY3 mutations have not been established in the medical literature. This gene follows Y-linked inheritance, being passed from father to son.

Summary from RefSeq
Research Assistant →
0
Active trials
1
Pubs (1 yr)
77
P/LP submissions
P/LP missense
LOEUF
Mechanism
Clinical SummaryTTTY3
📋
ClinVar Variants
77 unique Pathogenic / Likely Pathogenic· 12 VUS of 95 total submissions

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

95 submitted variants in ClinVar

Classification Summary

Pathogenic74
Likely Pathogenic3
VUS12
Likely Benign5
Benign1
74
Pathogenic
3
Likely Pathogenic
12
VUS
5
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
74
Likely Pathogenic
3
VUS
12
Likely Benign
5
Benign
1
Total95

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TTTY3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found