TTTY14
Chr Ytestis expressed transcript, Y-linked 14
Also known as: CYorf14, NCRNA00137, NCRNA00185, PRO2834, TTY14
The protein is predicted to bind pre-mRNA 5'-splice sites and participate in mRNA 5'-splice site recognition as part of the U1 small nuclear ribonucleoprotein complex. TTTY14 is located on the Y chromosome, so mutations would follow Y-linked inheritance affecting only males. No specific diseases have been established for this gene based on the available information.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
96 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 69 |
Likely Pathogenic | — | — | — | — | 2 |
VUS | — | — | — | — | 12 |
Likely Benign | — | — | — | — | 9 |
Benign | — | — | — | — | 2 |
Conflicting | — | 1 | |||
| Total | — | 95 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TTTY14 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools