TTTY12

Chr Y

testis expressed transcript, Y-linked 12

Also known as: NCRNA00135, TTY11, TTY12

I cannot provide a clinical summary for TTTY12 as no information about this gene's protein function, associated diseases, or inheritance pattern was provided in the data below the instructions.

DNmechanism

Population Genetics & Constraint

Constraint data not available from gnomAD.

DN
0.6259th %ile
GOF
0.3094th %ile
LOF
0.52top 25%

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TTTY12 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found