TSPYL5
Chr 8TSPY like 5
The protein binds chromatin and histones to regulate cell growth and DNA damage responses, particularly through modulation of the Akt signaling pathway and suppression of p53 protein levels. This highly constrained gene (pLI 0.85, LOEUF 0.45) has not yet been definitively associated with human disease, though its critical role in DNA damage response pathways suggests potential clinical relevance. Further research is needed to establish any disease associations and inheritance patterns.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TSPYL5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools