TSPYL1

Chr 6

TSPY like 1

Also known as: TSPYL

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]

GeneReviewsResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtSudden infant death with dysgenesis of the testes syndrome
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.32
LOEUF
GOF
Mechanism· predicted
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GeneReview available — TSPYL1
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.32LOEUF
pLI 0.000
Z-score 0.69
OE 0.80 (0.501.32)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.42Z-score
OE missense 0.92 (0.831.03)
230 obs / 248.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.80 (0.501.32)
00.351.4
Missense OE?0.92 (0.831.03)
00.61.4
Synonymous OE?1.43
01.21.6
LoF obs/exp: 11 / 13.8Missense obs/exp: 230 / 248.9Syn Z: -3.34

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TSPYL1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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