TSNAX-DISC1

Chr 1

TSNAX-DISC1 readthrough (NMD candidate)

This gene represents a naturally occurring read-through transcript between the neighboring TSNAX and DISC1 genes that produces multiple splice variants targeted for nonsense-mediated decay and is unlikely to encode functional protein. Alterations in the processing of this transcript may be associated with increased risk for psychiatric illness, particularly schizophrenia. The inheritance pattern and specific disease mechanisms remain unclear given the complex nature of this read-through transcript.

ResearchSummary from RefSeq

This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]

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Clinical Summary— TSNAX-DISC1

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