TRPM2
Chr 21transient receptor potential cation channel subfamily M member 2
Also known as: EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TRPM2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
RECRUITINGTRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients
ACTIVE NOT RECRUITINGCardiovascular Structure and Function in the Mucopolysaccharidoses
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools