TRPC5
Chr Xtransient receptor potential cation channel subfamily C member 5
Also known as: PPP1R159, TRP5
The protein forms a receptor-activated non-selective calcium permeant cation channel that regulates neuronal calcium influx and controls hypothalamic-mediated behaviors including feeding, anxiety, socialization, and maternal care. Loss-of-function mutations cause autosomal dominant neurodevelopmental disorders with extremely high constraint scores indicating severe intolerance to protein-truncating variants. The pathogenic mechanism involves disrupted calcium signaling leading to impaired neuronal function and altered innate behaviors.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
This gene has evidence for multiple mechanisms of pathogenicity (loss-of-function and gain-of-function). The Badonyi & Marsh model scores gain-of-function highest among its predictions, but genomic evidence (constraint, ClinVar variant spectrum, and literature) most strongly supports loss-of-function (haploinsufficiency). Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
300 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 12 | 0 | 12 |
Likely Pathogenic | 0 | 0 | 0 | 0 | 0 |
VUS | 2 | 75 | 4 | 0 | 81 |
Likely Benign | 0 | 5 | 8 | 52 | 65 |
Benign | 0 | 0 | 0 | 2 | 2 |
Conflicting | — | 1 | |||
| Total | 2 | 80 | 24 | 54 | 161 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
TRPC5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools