TRMT9B

Chr 8

tRNA methyltransferase 9B (putative)

Also known as: C8orf79, KIAA1456, TRM9L, hTRM9L

Enables tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.95
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.95LOEUF
pLI 0.000
Z-score -1.49
OE 1.62 (0.961.95)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-4.44Z-score
OE missense 1.79 (1.661.93)
445 obs / 248.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.62 (0.961.95)
00.351.4
Missense OE?1.79 (1.661.93)
00.61.4
Synonymous OE?1.65
01.21.6
LoF obs/exp: 11 / 6.8Missense obs/exp: 445 / 248.3Syn Z: -4.85

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TRMT9B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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