TRIML2

Chr 4

tripartite motif family like 2

Also known as: SPRYD6

NCBI Gene: 205860ENSG00000179046UniProt: Q8N7C3

This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Research Assistant →
0
Active trials
6
Pubs (1 yr)
109
P/LP submissions
0%
P/LP missense
1.29
LOEUF
Multiple*
Mechanism· predicted
Clinical Summary— TRIML2
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
109 unique Pathogenic / Likely Pathogenic· 79 VUS of 224 total submissions
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint
1.29LOEUF
pLI 0.000
Z-score 0.84
OE 0.74 (0.45–1.29)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.12Z-score
OE missense 0.98 (0.87–1.10)
208 obs / 213.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.74 (0.45–1.29)
0≤0.351.4
Missense OE0.98 (0.87–1.10)
0≤0.61.4
Synonymous OE1.01
0≤1.21.6
LoF obs/exp: 9 / 12.2Missense obs/exp: 208 / 213.0Syn Z: -0.04
DN
0.82top 10%
GOF
0.74top 25%
LOF
0.12100th %ile

This gene has evidence for multiple mechanisms of pathogenicity (dominant-negative and gain-of-function). Both the Badonyi & Marsh prediction and the broader genomic evidence point to dominant-negative as the predominant mechanism. Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.

DNprediction above median
GOFprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

224 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic98
Likely Pathogenic11
VUS79
Likely Benign26
Benign8
Conflicting1
98
Pathogenic
11
Likely Pathogenic
79
VUS
26
Likely Benign
8
Benign
1
Conflicting

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
98
0
98
Likely Pathogenic
0
0
11
0
11
VUS
0
54
25
0
79
Likely Benign
0
9
17
0
26
Benign
0
1
5
2
8
Conflicting
—1
Total0641562223

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRIML2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig
Eitel EK et al.·Reprod Fertil
2025
TRIML2 promotes malignant progression of head and neck squamous cell carcinoma via canonical Wnt signaling and tumor immune escape.
Luo X et al.·J Transl Med
2025
The Effects of Lentivirus-Mediated Gene Silencing of RARbeta on the Stemness Capability of Non-Small Cell Lung Cancer
Abu Halim NH et al.·J Cancer
2021
Integration RNA bulk and single cell RNA sequencing to explore the change of glycolysis-related immune microenvironment and construct prognostic signature in head and neck squamous cell carcinoma
Nie Q et al.·Transl Oncol
2024
Developing a pyroptosis-related gene signature to better predict the prognosis and immune status of patients with head and neck squamous cell carcinoma
Liu D et al.·Front Genet
2023Cohort
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 4 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients