TRIM77

Chr 11

tripartite motif containing 77

Also known as: TRIM77P

NCBI Gene: 390231 ENSG00000214414 UniProt: I1YAP6

The protein is predicted to function as a ubiquitin protein ligase involved in innate immune response and gene expression regulation. Mutations in this gene have not been definitively associated with human disease. The gene appears to tolerate loss-of-function variants well based on population genetics data.

ResearchSummary from RefSeq

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.31

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.31LOEUF

pLI 0.000

Z-score 0.80

OE 0.75 (0.45–1.31)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

1.22Z-score

OE missense 0.77 (0.68–0.88)

172 obs / 223.1 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.75 (0.45–1.31)

0≤0.351.4

Missense OE?0.77 (0.68–0.88)

0≤0.61.4

Synonymous OE?0.84

0≤1.21.6

LoF obs/exp: 9 / 12.0Missense obs/exp: 172 / 223.1Syn Z: 1.10

Background carrier burden — how many people carry a rare variant somewhere in TRIM77?

gnomAD v4 · ~700k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 95

501 rare PASS variants

Rare truncating (LoF)

1 in 1,200

72 rare PASS variants

Rare synonymous (reference)

1 in 240

169 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for TRIM77. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~540k	1 in 120	1 in 1,300
South Asian	~40k	1 in 90	1 in 1,300
Remaining (unassigned)	~29k	1 in 100	1 in 2,300
European (Finnish)	~25k	1 in 380	1 in 2,800
African / African American	~21k	1 in 96	1 in 620
East Asian	~18k	1 in 160	1 in 610
Admixed American	~18k	1 in 96	1 in 1,200
Ashkenazi Jewish	~13k	1 in 660	≈ 1 in 11,000
Middle Eastern	~2,852	1 in 82	≈ 1 in 930

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): 4 of 6 coding exons well covered in gnomAD exomes; exons 2, 5 marginal. Genomes: all 6.? see exons ↓