TRIM67

Chr 1

tripartite motif containing 67

Also known as: TNL

NCBI Gene: 440730ENSG00000119283UniProt: Q6ZTA4OMIM: 610584

The protein is predicted to bind zinc ions and regulate protein localization, with involvement in Ras signaling regulation, neuron projection development, and ubiquitin-mediated protein degradation in the cytoplasm and cytoskeleton. TRIM67 is highly constrained against loss-of-function variants (pLI=0.97, LOEUF=0.33), suggesting mutations may cause severe developmental disorders, though specific disease associations have not yet been established. The inheritance pattern for TRIM67-related conditions has not been determined.

OMIMResearchSummary from RefSeq
LOEUF 0.33
Clinical Summary— TRIM67
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 0.97). One damaged copy is likely sufficient to cause disease.
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint
0.33LOEUF
pLI 0.965
Z-score 4.21
OE 0.14 (0.07–0.33)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint
1.74Z-score
OE missense 0.76 (0.70–0.84)
325 obs / 426.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.14 (0.07–0.33)
0≤0.351.4
Missense OE0.76 (0.70–0.84)
0≤0.61.4
Synonymous OE1.02
0≤1.21.6
LoF obs/exp: 4 / 28.1Missense obs/exp: 325 / 426.1Syn Z: -0.24

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TRIM67 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Remimazolam Inhibits Neuronal Apoptosis, Inflammation, and Ferroptosis in Cerebral Infarction via Promoting TRIM67-Mediated Degradation of ACSL4.
Xiao G et al.·J Biochem Mol Toxicol
2026
TRIM67 Suppresses Glioblastoma Glycolysis and Increases Temozolomide Sensitivity by Promoting ARSD Ubiquitinated Degradation to Inactivate the β-Catenin Pathway.
Li X et al.·FASEB J
2025
Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis.
Ho CT et al.·J Cell Biol
2025
Effect of TRIM67 knockout on inflammation and macrophage survival in Salmonella Typhimurium-infected mice.
Chen S et al.·Arch Microbiol
2025
The Impact of TRIM67 Knockout on Early Intestinal Antimicrobial Capacity in Mice Infected with Salmonella enterica serovar Typhimurium ATCC 14028.
Zhang X et al.·Microorganisms
2025Open Access
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients