TRIM67

Chr 1

tripartite motif containing 67

Also known as: TNL

NCBI Gene: 440730 ENSG00000119283 UniProt: Q6ZTA4 OMIM: 610584

The protein is predicted to bind zinc ions and regulate protein localization, with involvement in Ras signaling regulation, neuron projection development, and ubiquitin-mediated protein degradation in the cytoplasm and cytoskeleton. TRIM67 is highly constrained against loss-of-function variants (pLI=0.97, LOEUF=0.33), suggesting mutations may cause severe developmental disorders, though specific disease associations have not yet been established. The inheritance pattern for TRIM67-related conditions has not been determined.

OMIM ResearchSummary from RefSeq

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.33

LOEUF· LoF intol.

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Mechanism