TRIM64

Chr 11

tripartite motif containing 64

Also known as: C11orf28, TRIM64A

NCBI Gene: 120146 ENSG00000204450 UniProt: A6NGJ6

The TRIM64 protein is predicted to function as a ubiquitin protein ligase involved in innate immune responses and gene expression regulation in the cytoplasm. Currently, no established disease associations have been reported for mutations in this gene based on the available information.

ResearchSummary from RefSeq

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

—

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (2)

gnomad: Error: gnomAD API error: 400

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in TRIM64?

gnomAD v4 · ~373k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 320

37 rare PASS variants

Rare truncating (LoF)

1 in 6,500

5 rare PASS variants

Rare synonymous (reference)

1 in 1,100

12 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for TRIM64. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 7 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~284k	1 in 340	1 in 26,000
South Asian	~22k	1 in 410	none seen
Remaining (unassigned)	~15k	1 in 740	none seen
European (Finnish)	~15k	1 in 450	≈ 1 in 5,300
Admixed American	~13k	1 in 570	≈ 1 in 6,200
East Asian	~12k	1 in 1,200	none seen
African / African American	~6,338	1 in 400	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.