TRIM61

Chr 4

tripartite motif containing 61

Also known as: RNF35

NCBI Gene: 391712 ENSG00000183439 UniProt: Q5EBN2 OMIM: 619417

The TRIM61 protein functions as a ubiquitin protein ligase involved in innate immune responses and gene expression regulation in the cytoplasm. This gene is highly constrained against loss-of-function variants (pLI = 0.0001), suggesting mutations would likely cause severe disease, but no specific human genetic disorders have been definitively associated with TRIM61 mutations to date.

OMIM ResearchSummary from RefSeq

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.76

LOEUF

Multiple*

Mechanism· predicted