TRIM58

Chr 1

tripartite motif containing 58

Also known as: BIA2

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
16
Pubs (1 yr)
P/LP submissions
P/LP missense
1.56
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.56LOEUF
pLI 0.000
Z-score -0.08
OE 1.02 (0.681.56)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.42Z-score
OE missense 0.92 (0.831.03)
219 obs / 237.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.02 (0.681.56)
00.351.4
Missense OE?0.92 (0.831.03)
00.61.4
Synonymous OE?1.10
01.21.6
LoF obs/exp: 15 / 14.7Missense obs/exp: 219 / 237.1Syn Z: -0.76

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TRIM58 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →