TRIM38

Chr 6

tripartite motif containing 38

Also known as: RNF15, RORET

NCBI Gene: 10475ENSG00000112343UniProt: O00635

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

ResearchGenerating clinical summary…
0
Active trials
26
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.11
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.11LOEUF
pLI 0.000
Z-score 1.16
OE 0.72 (0.48–1.11)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.59Z-score
OE missense 0.90 (0.80–1.00)
227 obs / 253.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.72 (0.48–1.11)
0≤0.351.4
Missense OE?0.90 (0.80–1.00)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 15 / 20.7Missense obs/exp: 227 / 253.6Syn Z: 1.47

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TRIM38 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients