TRIM2
Chr 4ARtripartite motif containing 2
Also known as: CMT2R, RNF86
The TRIM2 protein is an E3 ubiquitin ligase that mediates proteasome-mediated degradation of target proteins and plays a neuroprotective role in neurons. Mutations cause Charcot-Marie-Tooth disease type 2R, an early-onset axonal neuropathy, with autosomal recessive inheritance. This gene is highly constrained against loss-of-function variants (pLI 1.0, LOEUF 0.27), indicating that heterozygous loss-of-function variants are likely not tolerated.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TRIM2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools