TRGC2

Chr 7

T cell receptor gamma constant 2

Also known as: TCRGC2, TRGC2(2X), TRGC2(3X)

NCBI Gene: 6967ENSG00000227191UniProt: P03986

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in T cell receptor signaling pathway and adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of gamma-delta T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

9
ClinVar variants
7
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRGC2
📋
ClinVar Variants
7 Pathogenic / Likely Pathogenic of 9 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

9 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic7
Likely Benign1
Benign1
7
Pathogenic
1
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————7
Likely Pathogenic
————0
VUS
————0
Likely Benign
————1
Benign
————1
Total—9

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRGC2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools