TREML2

Chr 6

triggering receptor expressed on myeloid cells like 2

Also known as: C6orf76, TLT-2, TLT2, dJ238O23.1

NCBI Gene: 79865ENSG00000112195UniProt: Q5T2D2

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

ResearchGenerating clinical summary…
0
Active trials
13
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.72
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.72LOEUF
pLI 0.000
Z-score -0.35
OE 1.11 (0.72–1.72)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.29Z-score
OE missense 0.94 (0.82–1.07)
161 obs / 171.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.11 (0.72–1.72)
0≤0.351.4
Missense OE?0.94 (0.82–1.07)
0≤0.61.4
Synonymous OE?1.03
0≤1.21.6
LoF obs/exp: 13 / 11.7Missense obs/exp: 161 / 171.8Syn Z: -0.21

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TREML2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients