TREM1

Chr 6

triggering receptor expressed on myeloid cells 1

Also known as: CD354, TREM-1

NCBI Gene: 54210ENSG00000124731UniProt: Q9NP99

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

ResearchGenerating clinical summary…
5
Active trials
152
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.02
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.02LOEUF
pLI 0.006
Z-score 1.52
OE 0.49 (0.25–1.02)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.08Z-score
OE missense 0.98 (0.85–1.13)
128 obs / 130.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.49 (0.25–1.02)
0≤0.351.4
Missense OE?0.98 (0.85–1.13)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 5 / 10.3Missense obs/exp: 128 / 130.7Syn Z: 0.36

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TREM1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients