TRDN
Chr 6ARtriadin
Also known as: CARDAR, CPVT5, TDN, TRISK
Triadin is an integral membrane protein of the sarcoplasmic reticulum that regulates calcium release through RYR1 and RYR2 channels, which is essential for skeletal and cardiac muscle contraction and normal skeletal muscle strength. Autosomal recessive mutations cause cardiac arrhythmia syndrome with or without skeletal muscle weakness. This gene is not highly constrained against loss-of-function variants, consistent with its recessive inheritance pattern.
Definitive — sufficient evidence for diagnostic panels
2 total gene-disease associations curated
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TRDN · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools