TRBV7-9

Chr 7

T cell receptor beta variable 7-9

Also known as: TCRB, TCRBV6S4A1, TCRBV7S9, TRBV79

Predicted to enable MHC protein binding activity and peptide antigen binding activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

28
ClinVar variants
20
Pathogenic / LP
pLI score
0
Active trials
Clinical SummaryTRBV7-9
📋
ClinVar Variants
20 Pathogenic / Likely Pathogenic· 2 VUS of 28 total submissions
Some data sources returned errors (2)

gnomad: Error: Gene not found

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

28 submitted variants in ClinVar

Classification Summary

Pathogenic19
Likely Pathogenic1
VUS2
Likely Benign3
Benign3
19
Pathogenic
1
Likely Pathogenic
2
VUS
3
Likely Benign
3
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
19
Likely Pathogenic
1
VUS
2
Likely Benign
3
Benign
3
Total28

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBV7-9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →