TRBV5-4

Chr 7

T cell receptor beta variable 5-4

Also known as: TCRBV5S4, TCRBV5S6A3N2T, TRBV54

NCBI Gene: 28611ENSG00000230099UniProt: A0A0C4DH59

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

26
ClinVar variants
20
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBV5-4
📋
ClinVar Variants
20 Pathogenic / Likely Pathogenic· 2 VUS of 26 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

26 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic19
Likely Pathogenic1
VUS2
Likely Benign1
Benign3
19
Pathogenic
1
Likely Pathogenic
2
VUS
1
Likely Benign
3
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————19
Likely Pathogenic
————1
VUS
————2
Likely Benign
————1
Benign
————3
Total—26

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBV5-4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for TRBV5-4

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools