TRBV29-1

Chr 7

T cell receptor beta variable 29-1

Also known as: TCRBV29S1, TCRBV4S1A1T, TRBV291

NCBI Gene: 28558ENSG00000232869UniProt: A0A5B7

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

38
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBV29-1
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 2 VUS of 38 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

38 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS2
Likely Benign12
Benign3
20
Pathogenic
1
Likely Pathogenic
2
VUS
12
Likely Benign
3
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————2
Likely Benign
————12
Benign
————3
Total—38

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBV29-1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for TRBV29-1

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools