TRBV28

Chr 7

T cell receptor beta variable 28

Also known as: TCRBV28S1, TCRBV3S1

NCBI Gene: 28559ENSG00000211753UniProt: A0A5B6

Predicted to enable peptide antigen binding activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

32
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBV28
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 2 VUS of 32 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

32 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS2
Likely Benign7
Benign2
20
Pathogenic
1
Likely Pathogenic
2
VUS
7
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————2
Likely Benign
————7
Benign
————2
Total—32

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBV28 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Expression and clinical significance of PD-1 in UCEC and its Impact on tumor.
Xing F et al.·Cell Mol Biol (Noisy-le-grand)
2023
Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity.
Jiang H et al.·J Biomed Sci
2022Functional
Identification and validation of an immune-relevant risk signature predicting survival outcome and immune infiltration in uveal melanoma.
Sun X et al.·Int Ophthalmol
2023
TCR β CDR3 repertoire remodeling in pediatric myocarditis reveals clonal expansion and disease-associated public clonotypes.
Lin X et al.·Front Immunol
2026Functional
Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope.
Brennan RM et al.·J Virol
2007
Analysis of the complementarity determining regions β-chain genomic rearrangement using high-throughput sequencing in periphery cytotoxic T lymphocytes of patients with chronic hepatitis B.
Huang Y et al.·Mol Med Rep
2016Cohort
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools