TRBJ2-3

Chr 7

T cell receptor beta joining 2-3

Also known as: TCRBJ2S3, TRBJ23

NCBI Gene: 28626ENSG00000211767UniProt: A0A0B4J200

Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

25
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBJ2-3
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 1 VUS of 25 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

25 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS1
Likely Benign3
20
Pathogenic
1
Likely Pathogenic
1
VUS
3
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————1
Likely Benign
————3
Benign
————0
Total—25

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBJ2-3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for TRBJ2-3

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools