TRBC2

Chr 7

T cell receptor beta constant 2

Also known as: TCRBC2

NCBI Gene: 28638ENSG00000211772UniProt: A0A5B9

Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Located in plasma membrane. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

25
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBC2
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 1 VUS of 25 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

25 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS1
Likely Benign3
20
Pathogenic
1
Likely Pathogenic
1
VUS
3
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————1
Likely Benign
————3
Benign
————0
Total—25

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBC2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM et al.·Nat Med
2017
Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry.
Horna P et al.·Blood Cancer J
2024
Expression and clinical significance of PD-1 in UCEC and its Impact on tumor.
Xing F et al.·Cell Mol Biol (Noisy-le-grand)
2023
Integrating Single-Cell RNA-Seq and Bulk RNA-Seq to Construct a Novel γδT Cell-Related Prognostic Signature for Human Papillomavirus-Infected Cervical Cancer.
Wang X et al.·Cancer Control
2024
Shared chemoresistance genes in ESCC and cervical Cancer: Insights from pharmacogenomics and Mendelian randomization.
Liu Z et al.·Int Immunopharmacol
2025
Dimorphism in the T-cell receptor constant region affects T-cell function, phenotype and HIV outcome.
Kaewpreedee P et al.·AIDS
2019
Assessing the Persistence and Relevance of Small T-LGL Clones via TRBC1 in a Flowcytometric Lymphoid Screening Tube.
Debunne N et al.·Int J Lab Hematol
2025
A practical approach to panel design, validation, and interpretation for the evaluation of T-cell neoplasms by flow cytometry.
Oak J et al.·Cytometry B Clin Cytom
2025Guideline
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools