TRBC1

Chr 7

T cell receptor beta constant 1

Also known as: BV05S1J2.2, TCRB, TCRBC1

NCBI Gene: 28639ENSG00000211751UniProt: P01850

Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Predicted to be located in plasma membrane. Predicted to be part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

25
ClinVar variants
21
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— TRBC1
📋
ClinVar Variants
21 Pathogenic / Likely Pathogenic· 1 VUS of 25 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

25 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic20
Likely Pathogenic1
VUS1
Likely Benign3
20
Pathogenic
1
Likely Pathogenic
1
VUS
3
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————20
Likely Pathogenic
————1
VUS
————1
Likely Benign
————3
Benign
————0
Total—25

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

TRBC1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers.
Nichakawade TD et al.·Nature
2024
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.
Maciocia PM et al.·Nat Med
2017
Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry.
Horna P et al.·Blood Cancer J
2024
T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics.
Shi M et al.·Mod Pathol
2020
TRBC1 in flow cytometry: Assay development, validation, and reporting considerations.
Devitt KA et al.·Cytometry B Clin Cytom
2024
[The expressional characteristics and diagnostic values of TRBC1 in mature T-cell lymphoma].
Zhang NH et al.·Zhonghua Xue Ye Xue Za Zhi
2022
Emerging Role of T-cell Receptor Constant β Chain-1 (TRBC1) Expression in the Flow Cytometric Diagnosis of T-cell Malignancies.
Horna P et al.·Int J Mol Sci
2021Review
Broadening the horizon: potential applications of CAR-T cells beyond current indications.
Karsten H et al.·Front Immunol
2023Review
Flow Cytometric Assessment of TRBC1 Expression for the Diagnosis of T-Cell Lymphoma: Clinical Utility and Pitfalls Related to T-Cell Clones of Uncertain Significance.
Yu S et al.·Int J Lab Hematol
2025
Diagnostic utility of the lymphoid screening tube supplemented with TRBC1 for the assessment of T-cell clonality.
Blomme S et al.·Int J Lab Hematol
2023
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Use of TRBC1 Immunohistochemistry in the Diagnosis of Hypopigmented Mycosis Fungoides.
Zhao J et al.·J Cutan Pathol
2026
TRBC1/TRBC2 Immunophenotyping Provides Added Value During the Diagnostic Workup of T-Cell Lymphoma.
Taylor J et al.·EJHaem
2025🔓 Open Access
Immunohistochemical evaluation of T cell receptor and T cell receptor beta constant 1 expression distinguishes benign and neoplastic immature T-cell populations and reveals discrete TRBC1/TCR phenotypes.
Chaudhary S et al.·J Hematop
2025🔓 Open Access
Dual TRBC1-CD3 Immunohistochemistry Shows High Diagnostic Utility in Differentiating Mycosis Fungoides/Sezary Syndrome From Reactive Inflammatory Dermatoses in Skin Biopsies.
Lewis NE et al.·Am J Surg Pathol
2026
Implementing TRBC1 immunohistochemistry in daily pathology practice.
Nardi V et al.·Histopathology
2026
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools