TRARG1

Chr 17

trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)

Also known as: BEC-1, DSPB1, IFITMD3, LOST1, TUSC5

Predicted to be involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Predicted to act upstream of or within vesicle fusion to plasma membrane. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
4
Pubs (1 yr)
P/LP submissions
P/LP missense
1.75
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.75LOEUF
pLI 0.001
Z-score 0.17
OE 0.92 (0.481.75)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.44Z-score
OE missense 1.11 (0.961.29)
129 obs / 115.8 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.92 (0.481.75)
00.351.4
Missense OE?1.11 (0.961.29)
00.61.4
Synonymous OE?1.19
01.21.6
LoF obs/exp: 5 / 5.4Missense obs/exp: 129 / 115.8Syn Z: -1.13

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TRARG1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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