TRAPPC14

Chr 7AR

trafficking protein particle complex subunit 14

Also known as: C7orf43, MAP11, MCPH25

Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly 25. [provided by Alliance of Genome Resources, Apr 2025]

OMIMResearchGenerating clinical summary…
ARLOEUF 0.491 OMIM phenotype
Clinical SummaryTRAPPC14
Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.25) despite low pLI — interpret in context.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint?
0.49LOEUF
pLI 0.181
Z-score 3.40
OE 0.25 (0.140.49)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
2.21Z-score
OE missense 0.65 (0.580.73)
205 obs / 315.8 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios?
LoF OE?0.25 (0.140.49)
00.351.4
Missense OE?0.65 (0.580.73)
00.61.4
Synonymous OE?1.12
01.21.6
LoF obs/exp: 6 / 24.0Missense obs/exp: 205 / 315.8Syn Z: -1.09

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TRAPPC14 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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