TRAPPC14
Chr 7ARtrafficking protein particle complex subunit 14
Also known as: C7orf43, MAP11, MCPH25
The protein is a specific subunit of the TRAPP II complex that functions in Golgi trafficking and mediates vesicle transport to the mother centriole during ciliogenesis. Mutations cause primary autosomal recessive microcephaly 25, with autosomal recessive inheritance. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.494), and the condition affects brain development with primary microcephaly present at birth.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TRAPPC14 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools