TPST1

Chr 7

tyrosylprotein sulfotransferase 1

Also known as: TANGO13A

NCBI Gene: 8460ENSG00000169902UniProt: O60507OMIM: 603125

Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in post-translational protein modification. Located in Golgi membrane. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
10
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.54
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.54LOEUF
pLI 0.292
Z-score 2.90
OE 0.24 (0.12–0.54)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
1.36Z-score
OE missense 0.74 (0.65–0.84)
155 obs / 210.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.24 (0.12–0.54)
0≤0.351.4
Missense OE?0.74 (0.65–0.84)
0≤0.61.4
Synonymous OE?0.87
0≤1.21.6
LoF obs/exp: 4 / 16.8Missense obs/exp: 155 / 210.3Syn Z: 0.84

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

TPST1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients