TPD52L3

Chr 9

TPD52 like 3

Also known as: D55, NYDSP25, TPD55, hD55

This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.54
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.54LOEUF
pLI 0.198
Z-score 0.98
OE 0.36 (0.131.54)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.23Z-score
OE missense 1.40 (1.201.65)
103 obs / 73.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.36 (0.131.54)
00.351.4
Missense OE?1.40 (1.201.65)
00.61.4
Synonymous OE?0.97
01.21.6
LoF obs/exp: 1 / 2.7Missense obs/exp: 103 / 73.4Syn Z: 0.11

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

TPD52L3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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