TP53TG1
Chr 7TP53 target 1
Also known as: LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1, TP53LC12
Clinical Summary— TP53TG1
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ClinVar Variants
2 Pathogenic / Likely Pathogenic· 1 VUS of 3 total submissions
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
3 submitted variants in ClinVar
Classification Summary
Pathogenic2
VUS1
2
Pathogenic
1
VUS
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 2 |
Likely Pathogenic | — | — | — | — | 0 |
VUS | — | — | — | — | 1 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 3 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →TP53TG1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote Retinoblastoma Progression by Sponging miR-33b
Wang H et al.·Cell Transplant
2021
Modulation of Colorectal Tumor Behavior via lncRNA TP53TG1-Lipidic Nanosystem
Masoumi F et al.·Pharmaceutics
2021
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF
Sun J et al.·Cell Death Dis
2022
LncRNA TP53TG1 Promotes the Growth and Migration of Hepatocellular Carcinoma Cells via Activation of ERK Signaling
Lu Q et al.·Noncoding RNA
2021
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
Serum TP53TG1 Serves as a Diagnostic Biomarker for Sepsis and Has a Predictive Value for Clinical Outcomes.
Li S et al.·APMIS
2025
Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer.
Diaz-Lagares A et al.·Proc Natl Acad Sci U S A
2016
Long noncoding RNA TP53TG1 suppresses the growth and metastasis of hepatocellular carcinoma by regulating the PRDX4/β-catenin pathway.
Chen B et al.·Cancer Lett
2021
Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.
Liao D et al.·Cell Cycle
2022
Comprehensive analysis of DRAIC and TP53TG1 in breast cancer luminal subtypes through the construction of lncRNAs regulatory model.
Motalebzadeh J et al.·Breast Cancer
2022Functional
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Emerging role of lncRNA TP53TG1 as a tumor regulator and biomarker in human malignancies.
Wang B et al.·Discov Oncol
2026
LncRNA TP53TG1 promotes the growth and osteo/dentinogenic differentiation of dental pulp stem cells by activating the Smad3 and JNK1/2 pathway.
Li T et al.·In Vitro Cell Dev Biol Anim
2025
Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy.
He H.·Discov Oncol
2025Open Access
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools