TNRC18
Chr 7trinucleotide repeat containing 18
Also known as: CAGL79, TNRC18A
TNRC18 encodes a chromatin reader protein that binds trimethylated histone H3K9 and recruits corepressor complexes to silence endogenous retroviruses. The gene is highly constrained against loss-of-function variants (pLI = 0.99, LOEUF = 0.29), but no definitive human disease associations have been established to date. Further research is needed to determine if TNRC18 variants cause neurodevelopmental disorders in humans.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Tolerant to missense variation
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TNRC18 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools