TNP2

Chr 16

transition protein 2

Also known as: TP2

NCBI Gene: 7142 ENSG00000178279 UniProt: Q05952 OMIM: 190232

TNP2 encodes transition nuclear protein 2, which facilitates the replacement of histones with protamines during sperm DNA condensation in developing spermatids. Mutations in TNP2 cause male infertility due to defective sperm production and function, inherited in an autosomal recessive pattern. The gene shows tolerance to loss-of-function variants (low constraint), consistent with its specialized role in male reproductive function.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including penetration of zona pellucida; positive regulation of protein processing; and sperm DNA condensation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in chromosome and nucleolus. Predicted to be part of nucleosome. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.78

LOEUF

Mechanism· predicted