TNFSF8
Chr 9TNF superfamily member 8
Also known as: CD153, CD30L, CD30LG, TNLG3A
The protein encoded by TNFSF8 is a cytokine that binds to TNFRSF8/CD30 and induces T-cell proliferation, while also inhibiting immunoglobulin class switching in B cells. The gene has a high probability of loss-of-function intolerance (pLI = 0.76) and low tolerance for missense variants (LOEUF = 0.525), suggesting mutations would likely cause disease, though specific neurogenetic disorders associated with TNFSF8 mutations have not been established in the provided information.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TNFSF8 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
External Resources
Links to major genomics databases and tools