TNFRSF10C
Chr 8TNF receptor superfamily member 10c
Also known as: CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID
The protein is a TNF receptor superfamily member that binds TRAIL ligand but lacks a cytoplasmic death domain, functioning as a decoy receptor that protects cells from TRAIL-induced apoptosis. This gene is loss-of-function tolerant and no Mendelian diseases have been established from mutations in TNFRSF10C. The protein is highly expressed in normal tissues but absent in most cancer cell lines, suggesting a role in protecting normal cells from cytotoxic signals.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
This gene has evidence for multiple mechanisms of pathogenicity (gain-of-function and dominant-negative). Both the Badonyi & Marsh prediction and the broader genomic evidence point to gain-of-function as the predominant mechanism. Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TNFRSF10C · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools