TMSB4Y
Chr Ythymosin beta 4 Y-linked
Also known as: TB4Y
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]
ResearchGenerating clinical summary…
Clinical highlights
Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.86LOEUF
pLI 0.319
Z-score 0.55
OE 0.00 (0.00–1.86)
Highly tolerant — LoF variants common in population
Missense Constraint?
-0.50Z-score
OE missense 1.64 (0.88–1.95)
8 obs / 4.9 exp
Tolerant to missense variation
Observed / Expected Ratios?
LoF OE?0.00 (0.00–1.86)
0≤0.351.4
Missense OE?1.64 (0.88–1.95)
0≤0.61.4
Synonymous OE?2.11
0≤1.21.6
LoF obs/exp: 0 / 0.4Missense obs/exp: 8 / 4.9Syn Z: -0.85
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMSB4Y · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools