TMSB4X
Chr Xthymosin beta 4 X-linked
Also known as: FX, PTMB4, TB4X, TMSB4
This protein binds and sequesters actin monomers to inhibit actin polymerization, playing an important role in cytoskeletal organization. Mutations cause X-linked intellectual disability with cardiac arrhythmias and skeletal abnormalities. The gene escapes X-inactivation and shows X-linked inheritance affecting multiple organ systems including the nervous system, heart, and skeletal development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
TMSB4X · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools